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UTech, Ja:Dr. Andrew Lamm and Dr. Denise Daley Publish Research Article on Jamaican Algae and their Anticancer Activity April 12, 2016

Posted by utechalumni in Uncategorized, UTech News.
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Andrew Lamm

Dr. Andrew Lamm


Dr. Denise Daley

Dr. Andrew Lamm and Dr. Denise Daley Publish Research Article on Jamaican Algae and their Anticancer Activity

Dr. Andrew Lamm, Director of the Centre for Science-based Research, Entrepreneurship and Continuing Studies (CSRECS) and the Natural Products Research Laboratory (NPRL), Faculty of Science and Sport; and Dr. Denise Daley, Programme Director, College of Health Sciences have published a research article titled “Anticancer Activity of Three Jamaican Macroalgae against Prostate, Pancreatic and Skin Cancers“. The article is co-authored by Dr. Henry I. C. Lowe, Dr. Charah Watson, Mrs. Shelly-Ann Powell, Dr. Kenneth N. N. Ayeah, Dr. Ngeh J. Toyang and Prof. Joseph Bryant. This represents a collaboration between UTech, Jamaica and Bio-Tech R&D Institute (Jamaica); Educational and Scientific Corporation (USA); and the Institute of Human Virology, University of Maryland School of Medicine (USA). The article is published in the European Journal of Medicinal Plants, 13(2): 1-5, 2016. The article can be accessed at http://sciencedomain.org/issue/1699.



Aims: Cancer is one of the leading chronic diseases that may lead to death. The search for new therapeutic, medicinal and nutraceutical compounds from folkloric plants including the marine flora are globally important objectives. Therefore the biological assessment of macroalgae is critical. Methodology: Three macroalgae, Galaxaura oblongata, Dictyota cervicornis and Halimeda incrassata were collected from the southern coast of Jamaica and assessed for their anticancer activity against prostate, pancreatic and skin (melanoma) cancers using PC-3, MiaPaca-2 and A375 cell lines respectively. The crude hexane, ethyl acetate and methanol extracts were prepared and bio-assayed using the WST-1 cell proliferation assay. Results: The results indicated that the crude ethyl acetate extract for three of the macroalgae; Galaxaura oblongata, Dictyota cervicornis and Halimeda incrassata; had significant activity against A375 cell line with IC50 values of 8.432, 7.48, 6.691 μg/ml respectively. No significant effect was observed against melanoma cells for neither the crude hexane nor the methanol extracts, as well as there were no significant effect on the prostate or pancreatic cell lines for all crude extracts. Conclusion: These results indicate the potency and product potential of the edible marine macroalgae as a functional food and nutraceuticalThis report represents the first scientific bioassay of the Jamaican species of these algae.




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